Login

Oral Sphere

Journal of Dental and Health Sciences

COPE Member

USAG-1 Inhibition: Paving the Way for Lab-Grown Tooth Regeneration in Modern Dentistry

Volume 1, Issue 4 - 2025

Review Article

Sajda Khan Gajdhar

Received: 2025-06-01

Accepted: 2025-09-15

Published: 2025-10-01

DOI: 10.63150/osjdhs.2025.29

Pages: 268-271

Abstract

Tooth loss is a prevalent health issue that traditional solutions address through either prosthodontic restorations or dental implants. Laboratory-produced bioengineered teeth are no longer a scientific speculation, as regenerative medicine continues to make innovative progress. The critical advancement within this research area relies on USAG-1 (Uterine Sensitization Associated Gene-1) gene suppression which blocks tooth development. Scientists have shown that USAG-1 inhibition leads to supernumerary tooth growth through recent studies thereby creating a modern dental therapeutic option. The investigative analysis reviews existing knowledge about lab-grown teeth to explore USAG-1 regulation of dental tissue regeneration together with potential treatments despite implementation barriers.

Keywords: Bioengineering, Gene Editing, Regenerative Dentistry, Tooth Regeneration, USAG-1 Inhibition

References

 

  1. Ong G. et al. Int Dent J. 1998 Jun;48(3 Suppl 1):233-8. [PMID: 9779103]
  2. Gasner NS et al. Periodontal Disease. [Updated 2025 May 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: [https://www.ncbi.nlm.nih.gov/books/NBK554590/]
  3. Rakhshan V et al. Dent Res J (Isfahan). 2015 Jan-Feb;12(1):1-13. [PMID: 25709668]
  4. Taban M et al. Eur J Transl Myol. 2023 Nov 21;33(4):11727. [PMID: 37990970]
  5. Dutta SR et al. Natl J Maxillofac Surg. 2020 Jan-Jun;11(1):14-19. Epub 2020 Jun 18. [PMID: 33041571]
  6. Thalakiriyawa DS et al. Int Dent J. 2024 Feb;74(1):25-34. Epub 2023 Aug 2. [PMID: 37541918]
  7. Kaur T et al. J Pharm Bioallied Sci. 2024 Dec;16 (Suppl 4): S3041-S3043. Epub 2024 Nov 13. [PMID: 39926970]
  8. Murashima-Suginami A et al. Sci Adv. 2021 Feb 12;7(7):eabf1798 [PMID: 33579703]
  9. Liu M et al. Cells. 2022; 11(14):2216. [DOI: 10.3390/cells11142216]
  10. Ravi V et al. Regen Ther. 2023 Feb 3;22:160-168. [PMID: 36819612]
  11. Siddique N et al. Genes (Basel). 2016 Nov 10;7(11):98. [PMID: 27834914]
  12. Li X et al. J Immunol Res. 2021 Aug 7;2021:9752139. [PMID: 34414243]
  13. Zhang F et al. Genes Dis. 2016 Dec;3(4):263-276. [PMID: 28491933]
  14. Saito K et al. BMC Dev Biol 16, 14 (2016[DOI:10.1186/s12861-016-0117-x]
  15. Takahashi K et al. Inflamm Regener 40, 21 (2020). [DOI:10.1186/s41232-020-00130-x]
  16. Sui Y et al. Cell Regen 14, 33 (2025). [DOI: 10.1186/s13619-025-00249-7]
  17. https://www.dentinova.co.uk/2025/05/01/tooth-regeneration-with-human-anti-usag-1-therapy/ [Last accessed: 06/09/2025]
  18.  https://jstories.media/article/the-worlds-first-drug-that-helps-patients-grow-new-teeth-update [Last accessed: 06/09/2025]
  19.  https://adanews.ada.org/huddles/can-teeth-be-regrown/#:~:text=by%20ADA%20Huddles,no%20side%20effects%20present%20themselves. [Last accessed: 06/09/2025]
  20. https://conciergedentalgroup.com/blog/tooth-regrowth-drug/ [Last accessed: 06/09/2025]
Article Metrics
240 Views
73 Downloads
Actions
Download PDF
Altmetrics
PlumX Metrics
Citations (Dimensions)
Altmetric Score
CrossRef Citations
--

Loading...

Google Scholar
View in Scholar